Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

Overcoming alcohol cravings isn’t about willpower — it’s about changing how the brain reacts to alcohol. That’s where Naltrexone comes in. This medication, when used correctly, can interrupt the reward cycle that fuels compulsive drinking. In this guide, we’ll explore exactly how Naltrexone works, what cravings really are, and how this medication rewires the brain's response to alcohol.
The Sunday Reset
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